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I've never had a reaction to any antibiotics, but this one brought me to the ER. After 24 hours I began feeling flu like symptoms, 48 hours later I had symptoms of bronchitis, after 4 days I was covered in hives. I had assumed that I picked up a virus from the clinic when I went in for the urinary tract infection, so I didn't correlate all my symptoms to reactions from the Macrobid. When I broke out into hives, I finally realized something was going on. After a visit to the ER and steroids, I'm feeling better. It's been 24 hours off the Macrobid, and I can breathe again, flu symptoms gone, and I have my energy back. That was a rough 6 days in bed.